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TPO-ELISA Kit

TPO-ELISA Kit
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Product Detail


Product name:TPO ELISA Kit
Specification:
96test
Description:

Thrombopoietin (Tpo), also known as megakaryocyte growth and development factor (MGDF), the ligand for the receptor encoded by the c-Mplproto-oncogene, is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitroand in vivo. Tpo has been purified and cloned from several species including mouse, mouse, rat, and dog. Mature Tpo can be divided into two domains: the amino-terminal half with homology to erythropoietin (Epo) and the carboxy-terminal half rich in serine, threonine and proline residues and containing seven potential N-linked glycosylation sites. The Epo-domain of mouse Tpo shows approximately 21% amino acid sequence identity to mouse Epo and has been shown to activate the c-Mplreceptor. The carboxy terminus domain of Tpo has been shown to regulate the specific activity and circulating half-life of Tpo. The carboxy-terminal may also have a role in promoting the efficient biosynthesis and secretion of Tpo. The cDNA for a variant form of Tpo (Tpo-2) with a four amino acid residue deletion within the Epo homology domain has been isolated. Tpo-2 is very poorly secreted and lacks Tpo activity. Tpo mRNA is expressed predominantly in adult and fetal liver, kidney and bone marrow stromal cells.

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