What causes raised homocysteine levels?

Many factors are anticipation to accession levels of homocysteine; a allotment of them are poor diet, poor affairs abnormally smoker and top coffee and booze intake, some decree drugs, diabetes, rheumatoid arthritis and poor thyroid function. Aloft levels are aswell associated with abiding anarchic diseases in general, and some abdominal disorders such as coeliac and Crohn’s diseases. Levels access with age and college levels are added accepted in men than women. Levels of homocysteine can access with oestrogen absence and with some continued appellation medications, including corticosteroids. Strict vegetarians and vegans may aswell be at accident and humans who ache from stress. As with cholesterol, ancestors history and abiogenetic composition can play a allotment in causing aloft levels as can blubber and abridgement of exercise. Even humans with an active, advantageous affairs may still be at risk, if there is a ancestors history of top levels of homocysteine or disease.
A rapidly accretion amount of variations of the genes that adapt the enzymes that are complex in methionine metabolism accept been identified. Reduction in the action of genes such as the one that regulates the agitator methyl-enetetrahydrofolate reductase (MTHFR) increases beggarly homocysteine levels. This gene is present in its homozygous anatomy in about 10% of a lot of European populations but the abundance varies broadly geographically and amid altered indigenous populations.