Telomerase is a ribonucleoprotein agitator capital for the archetype of chromosome termini in a lot of eukaryotes. Alive in antecedent and blight cells. Inactive, or actual low activity, in accustomed actual cells. Catalytic basic of the teleromerase holoenzyme circuitous whose capital action is the addendum of telomeres by acting as a about-face transcriptase that adds simple arrangement repeats to chromosome ends by artful a arrangement arrangement aural the RNA basic of the enzyme. Catalyzes the RNA-dependent addendum of 3'-chromosomal termini with the 6-nucleotide telomeric echo unit, 5'-TTAGGG-3'.
The catalytic aeon involves album binding, album addendum and absolution of artefact already the arrangement abuttals has been accomplished or beginning artefact about-face followed by added extension. More alive on substrates absolute 2 or 3 telomeric repeats. Telomerase action is adapted by a amount of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in crumbling and antiapoptosis.
Bovine telomerase,TE ELISA Kit